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Help to go: T cells transfer CD40L to antigen-presenting B cells

被引：13
作者：
Dustin, Michael L. [1 ]
机构：
[1] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthoped Rheumatol & Musculoskeleta, Oxford OX1 2JD, England
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2017年 / 47卷 / 01期
基金：
英国惠康基金;
关键词：
CD40; ligand; (CD40L; CD154); Costimulation; Cytokines; Exosomes; Immunological synapse; Juxtracrine; Membrane transfer; Paracrine; T-cell help; IMMUNOLOGICAL SYNAPSE; ACTIVATION; EXOSOMES; LIGAND; MICROVESICLES; SECRETION; VESICLES; IMMUNITY; COMPLEX; MEMORY;
D O I：
10.1002/eji.201646786
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
071005 [微生物学]; 100108 [医学免疫学];
摘要：
Most immune cell communication takes place by intercellular transfer of cytokines or the contact-dependent interaction of surface receptors in immunological synapses. In this issue of the European Journal of Immunology, Gardell and Parker (Eur. J. Immunol. 2017, 47, 41-50) point to a new, hybrid mechanism for Th1-cell delivery of help to B cells, based on contact-dependent CD40L transfer. The transfer process and its specificity are both cell contact dependent and antigen dependent. CD40 expression is also required on the B-cell surface to capture the CD40L presented by the Th1 cell. While further studies are needed to confirm the phenomenon in vivo and to test the role of transferred CD40L in other aspects of T-cell help, this study provides an exceptional take-off point and makes excellent use of mouse genetics to work out some possible rules for B cells being able to order help 'to go'.
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页码：31 / 34
页数：4
相关论文
共 26 条
[1]
Imaging of germinal center selection events during affinity maturation [J].
Allen, Christopher D. C. ;
Okada, Takaharu ;
Tang, H. Lucy ;
Cyster, Jason G. .
SCIENCE, 2007, 315 (5811) :528-531
[2]
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells [J].
Black, RA ;
Rauch, CT ;
Kozlosky, CJ ;
Peschon, JJ ;
Slack, JL ;
Wolfson, MF ;
Castner, BJ ;
Stocking, KL ;
Reddy, P ;
Srinivasan, S ;
Nelson, N ;
Boiani, N ;
Schooley, KA ;
Gerhart, M ;
Davis, R ;
Fitzner, JN ;
Johnson, RS ;
Paxton, RJ ;
March, CJ ;
Cerretti, DP .
NATURE, 1997, 385 (6618) :729-733
[3]
TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex [J].
Blanchard, N ;
Lankar, D ;
Faure, F ;
Regnault, A ;
Dumont, C ;
Raposo, G ;
Hivroz, C .
JOURNAL OF IMMUNOLOGY, 2002, 168 (07) :3235-3241
[4]
Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites [J].
Boisvert, J ;
Edmondson, S ;
Krummel, MF .
JOURNAL OF IMMUNOLOGY, 2004, 173 (06) :3647-3652
[5]
A SUBSET OF CD4(+) MEMORY T-CELLS CONTAINS PREFORMED CD40 LIGAND THAT IS RAPIDLY BUT TRANSIENTLY EXPRESSED ON THEIR SURFACE AFTER ACTIVATION THROUGH THE T-CELL RECEPTOR COMPLEX [J].
CASAMAYORPALLEJA, M ;
KHAN, M ;
MACLENNAN, ICM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (04) :1293-1301
[6]
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse [J].
Choudhuri, Kaushik ;
Llodra, Jaime ;
Roth, Eric W. ;
Tsai, Jones ;
Gordo, Susana ;
Wucherpfennig, Kai W. ;
Kam, Lance C. ;
Stokes, David L. ;
Dustin, Michael L. .
NATURE, 2014, 507 (7490) :118-+
[7]
What Counts in the Immunological Synapse? [J].
Dustin, Michael L. .
MOLECULAR CELL, 2014, 54 (02) :255-262
[8]
Gardell J. M., 2016, EUR J IMMUNOL
[9]
A SOLUBLE FORM OF TRAP (CD40 LIGAND) IS RAPIDLY RELEASED AFTER T-CELL ACTIVATION [J].
GRAF, D ;
MULLER, S ;
KORTHAUER, U ;
VANKOOTEN, C ;
WEISE, C ;
KROCZEK, RA .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (06) :1749-1754
[10]
The ESCRT complexes [J].
Hurley, James H. .
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2010, 45 (06) :463-487
123