The ESCRT complexes

被引：284

作者：

Hurley, James H. ^{[1
]}

机构：

[1] NIDDKD, Mol Biol Lab, NIH, US Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2010年 / 45卷 / 06期

关键词：

EPIDERMAL-GROWTH-FACTOR; LEUKEMIA-VIRUS TYPE-1; MULTIVESICULAR BODY PATHWAY; UBIQUITIN-BINDING DOMAINS; LATE-BUDDING DOMAINS; TUMOR SUSCEPTIBILITY GENE-101; ENDOSOME-ASSOCIATED COMPLEX; VESICULAR-STOMATITIS-VIRUS; PROTEIN-COUPLED RECEPTOR; AAA-ATPASE VPS4;

D O I：

10.3109/10409238.2010.502516

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0, -I, -II, -III, and Vps4-Vta1, and the ALIX homodimer. The ESCRT system is required for degradation of unneeded or dangerous plasma membrane proteins; biogenesis of the lysosome and the yeast vacuole; the budding of most membrane enveloped viruses; the membrane abscission step in cytokinesis; macroautophagy; and several other processes. From their initial discovery in 2001-2002, the literature on ESCRTs has grown exponentially. This review will describe the structure and function of the six complexes noted above and summarize current knowledge of their mechanistic roles in cellular pathways and in disease.</.

引用

页码：463 / 487

页数：25

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