Cytogenetic studies of three triazine herbicides I. In vitro studies

被引：36

作者：

Kligerman, AD

Doerr, CL

Tennant, AH

Zucker, RM

机构：

[1] US EPA, Div Environm Carcinogenesis, Genet & Cellular Toxicol Branch, Res Triangle Pk, NC 27711 USA

[2] US EPA, Reprod Toxicol Div, Res Triangle Pk, NC 27711 USA

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2000年 / 465卷 / 1-2期

关键词：

triazine; chromosome damage; sister chromatid exchange; human lymphocytes;

D O I：

10.1016/S1383-5718(99)00211-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Atrazine, simazine, and cyanazine are widely used pre-emergence and post-emergence triazine herbicides that have made their way into the potable water supply of many agricultural communities, Because of this and the prevalence of contradictory cytogenetic studies in the literature on atrazine, simazine, and cyanazine, a series of in vitro experiments was performed to investigate the ability of these three triazines to induce sister chromatid exchanges (SCEs) and chromosome aberrations (CAs) in human lymphocyte cultures. Our results showed that all three triazines failed to produce any significant increases in SCEs or CAs up to the limits of solubility [using 0.5% dimethyl sulfoxide (DMSO)]. Our results are discussed in light of contradictory results in the literature. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：53 / 59

页数：7