Self-Assembled Fmoc-Peptides as a Platform for the Formation of Nanostructures and Hydrogels

被引：289

作者：

Orbach, Ron ^{[1
]}

Adler-Abramovich, Lihi ^{[1
]}

Zigerson, Sivan ^{[2
]}

Mironi-Harpaz, Iris ^{[2
]}

Seliktar, Dror ^{[2
]}

Gazit, Ehud ^{[1
]}

机构：

[1] Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, George S Wise Fac Life Sci, IL-6407536 Tel Aviv, Israel

[2] Technion Israel Inst Technol, Fac Biomed Engn, IL-32000 Haifa, Israel

来源：

BIOMACROMOLECULES | 2009年 / 10卷 / 09期

关键词：

3-DIMENSIONAL CELL-CULTURE; NANOCRYSTAL GROWTH; NANOFIBER SCAFFOLD; NANOTUBES; NANOWIRES; PROTEIN; FORM; REGENERATION; ARCHITECTURE; AGGREGATION;

D O I：

10.1021/bm900584m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogels are of great interest as a class of materials for tissue engineering, axonal regeneration, and controlled drug delivery, as they offer 3D interwoven scaffolds to support the growth of cells. Herein, we extend the family of the aromatic Fmoc-dipeptides with a library of new Fmoc-peptides, which include natural and synthetic amino acids with an aromatic nature. We describe the self-assembly of these Fmoc-peptides into various structures and characterize their distinctive molecular and physical properties. Moreover, we describe the fabrication of the bioactive RGD sequence into a hydrogel. This unique material offers new opportunities for developing cell-adhesive biomedical hydrogel scaffolds, as well as for establishing strategies to modify surfaces with bioactive materials.

引用

页码：2646 / 2651

页数：6

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