Obesity, inflammation, and atherosclerosis

被引：738

作者：

Rocha, Viviane Z. ^{[1
]}

Libby, Peter ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Div Cardiovasc Med, Dept Med,Med Sch, Boston, MA 02115 USA

来源：

NATURE REVIEWS CARDIOLOGY | 2009年 / 6卷 / 06期

关键词：

C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; LOW-DENSITY-LIPOPROTEIN; INDUCED INSULIN-RESISTANCE; RECEPTOR-DEFICIENT MICE; NECROSIS-FACTOR-ALPHA; SMOOTH-MUSCLE-CELLS; E-KNOCKOUT MICE; DIET-INDUCED ATHEROSCLEROSIS; RANDOMIZED CONTROLLED-TRIAL;

D O I：

10.1038/nrcardio.2009.55

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Understanding of the pathophysiology of atherogenesis has evolved substantially during the last few decades. Atherosclerosis was once identified as a lipid-storage disease, but is now recognized as a subacute inflammatory condition of the vessel wall, characterized by infiltration of macrophages and T cells, which interact with one another and with cells of the arterial wall. The pathological mechanisms of obesity recapitulate many features of the inflammatory processes at work in atherosclerosis. Our current appreciation of the similarities between obesity and atherosclerosis has already fostered innovations for the diagnosis, prognosis, and prevention of these two conditions.

引用

收藏

页码：399 / 409

页数：11

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