Review of immunosuppression for lung transplantation: Novel drugs, new uses for conventional immunosuppressants, and alternative strategies

被引：24

作者：

Hausen, B ^{[1
]}

Morris, RE ^{[1
]}

机构：

[1] STANFORD UNIV,SCH MED,DEPT CARDIOTHORAC SURG,STANFORD,CA 94305

来源：

CLINICS IN CHEST MEDICINE | 1997年 / 18卷 / 02期

关键词：

D O I：

10.1016/S0272-5231(05)70384-1

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The history, pharmacokinetics, mechanisms of action, and experimental as well as clinical data on the immunosuppressive potential of the novel drugs tacrolimus (FK506), sirolimus (rapamycin), mycophenolic acid (mycophenolate mofetil), and leflunomide (and its malononitriloamide analogues) are provided. Novel approaches with the following conventional immunosuppressants are outlined: methotrexate, aerosolized immunosuppression and the implementation of steroid taper. Total lymphoid irradiation and photopheresis for treatment of recurrent rejection are also discussed.

引用

页码：353 / &

页数：15

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