Rhodium-catalyzed asymmetric 1,4-addition of aryltitanium reagents generating chiral titanium enolates: Isolation as silyl enol ethers

被引：75

作者：

Hayashi, T ^{[1
]}

Tokunaga, N ^{[1
]}

Yoshida, K ^{[1
]}

Han, JW ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 41期

关键词：

D O I：

10.1021/ja027663w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The addition of aryltitanium triisopropoxide (ArTi(OPr-i )3) to α,β-unsaturated ketones proceeded with high enantioselectivity (94-99.8% ee) in the presence of 3 mol % of [Rh(OH)((S )-binap)]2 in THF at 20 °C to give high yields of the titanium enolates as 1,4-addition products. The titanium enolates were converted into silyl enol ethers by treatment with chlorotrimethylsilane and lithium isopropoxide. Copyright © 2002 American Chemical Society.

引用

页码：12102 / 12103

页数：2

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