Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism

被引：64

作者：

Gould, E ^{[1
]}

Tanapat, P ^{[1
]}

Cameron, HA ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,NEUROENDOCRINOL LAB,NEW YORK,NY 10021

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1997年 / 103卷 / 01期

关键词：

cell death; dentate gyrus; adrenal steroid; corticosterone; NMDA receptor; development;

D O I：

10.1016/S0165-3806(97)00079-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyrus in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation. (C) 1997 Elsevier Science B.V.

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页码：91 / 93

页数：3

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