L-DOPA-induced neurotoxic and apoptotic changes on cultured chromaffin cells

被引：14

作者：

Corona-Morales, AA

Castell, A

Zhang, LM ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico

来源：

NEUROREPORT | 2000年 / 11卷 / 03期

关键词：

apoptosis; chromaffin cells; L-DOPA; MTT; neurotoxicity; Parkinson's disease; tyrosine hydroxylase; TUNEL;

D O I：

10.1097/00001756-200002280-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adrenal chromaffin cell (ACC) transplantation has been considered as one of the therapeutic strategies for Parkinson disease (PD). This strategy involves the administration of L-DOPA, although in reduced doses, to ACC-transplanted patients. Using cytochemical and morphological methods, we examined the effects of clinically applicable concentrations of L-DOPA on cultured chromaffin cells. We found an increase of cell death in both necrotic and apoptotic patterns. These data suggest that therapeutic preventive measures during ACC transplantation processes for PD should be taken. NeuroReport 11:503-506 (C) 2000 Lippincott Williams & Wilkins.

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收藏

页码：503 / 506

页数：4

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