An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample

被引:20
作者
Kurumaji, A [1 ]
Nomoto, H [1 ]
Yoshikawa, T [1 ]
Okubo, Y [1 ]
Toru, M [1 ]
机构
[1] Tokyo Med & Dent Univ, Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138519, Japan
关键词
benzodiazepine receptor (peripheral); schizophrenia; single nucleotide polymorphism; association; missense; restriction fragment length polymorphism;
D O I
10.1007/s007020070090
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The benzodiazepine receptor (peripheral) (BZRP) mainly localized on glial cells plays a role in neurosteroid synthesis, and increases with glial proliferation. We have recently reported a significant decrease in the density of BZRP labeled by [H-3] pK 11195 in the postmortem brain of chronic schizophrenics, suggesting that dysfunctions of the BZRP are involved in the pathophysiology of schizophrenia. We screened 11 patients with schizophrenia and 10 controls, which were used in a previous postmortem study, for their genomic sequences of the BZRP gene in order to find DNA sequence variations. One novel missense polymorphism (His162Arg) and another previously reported missense mutation (Ala147Thr) were detected. An association study of the identified variations was then performed in an extended Japanese sample of 304 schizophrenic patients and 369 controls. While there was an increased tendency in the frequency of the 162Arg allele of schizophrenics compared to that of the controls (p = 0.0603), no statistically significant association with schizophrenia was observed in the Ala147Thr allele (p 0.1016). These results do not suggest that the two missense polymorphisms play a major role in the genetic predisposition of schizophrenia in the Japanese sample.
引用
收藏
页码:491 / 500
页数:10
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