Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes

被引：174

作者：

Saccani, S ^{[1
]}

Natoli, G ^{[1
]}

机构：

[1] Inst Biomed Res, CH-6501 Bellinzona, Switzerland

来源：

GENES & DEVELOPMENT | 2002年 / 16卷 / 17期

关键词：

histone methylation; transcriptional repression; histone methyltransferase; histone code;

D O I：

10.1101/gad.232502

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Methylation of histone H3 at Lys 9 is causally linked to formation of heterochromatin and to long-term transcriptional repression. We report an unexpected pattern of H3 Lys 9 methylation occurring at a subset of inducible inflammatory genes. This pattern is characterized by relatively low constitutive levels of H3 Lys 9 methylation that are erased upon activation and restored concurrently with post-induction transcriptional repression. Changes in H3 Lys 9 methylation strongly correlate with RNA polymerase 11 recruitment and release. In particular, remethylation correlates with RNApolII release more strongly than does histone deacetylation. We propose that, by generating a window of time in which transcription is permitted, dynamic modulation of H3 Lys 9 methylation adds an additional regulatory level to transcriptional activation of tightly controlled inducible genes.

引用

页码：2219 / 2224

页数：6

共 39 条

[1] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].