Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer

被引:194
作者
Dewan, M. Z.
Ahmed, S.
Iwasaki, Y.
Ohba, K.
Toi, M.
Yamamoto, N.
机构
[1] Tokyo Med & Dent Univ, Grad Sch, Dept Mol Virol, Bio Response,Bunkyo Ku, Tokyo 1138519, Japan
[2] Natl Inst Infect Dis, AIDS Res Ctr, Tokyo 1628640, Japan
[3] Tokyo Metropolitan Komagome Hosp, Tokyo Med Ctr Canc & Infect Dis, Div Clin Trials & Res, Breast Canc Res & Treatment Program,Bunkyo Ku, Tokyo, Japan
关键词
stromal cell-derived factor-1; CXCR4; receptor; breast cancer;
D O I
10.1016/j.biopha.2006.06.004
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Stromal cell-derived factor-1 (SDF-1)/CXCR4 interaction is critical for the trafficking of lymphocytes, homing and retention of hematopoietic stem cells within the bone marrow and is essential in fetal hematopoiesis. Binding of SDF-1 to CXCR4 activates a variety of intracellular signal transduction pathways and effector molecules that regulate cell survival, proliferation, chemotaxis, migration and adhesion. Recently, intensive research has demonstrated that SDF-1/CXCR4 interaction also regulates several key events in wide variety, of cancers. Serum-depleted media in the presence of SDF-1 protected the breast cancer cells from apoptosis. CXCR4-low-expressing MCF-7 formed small tumor at inoculated site in SCID mice 8-9 weeks after inoculation while completely failed to metastasis into various organs. In contrast, CXCR4-high-expressing MDA-231 cells were most efficient in the formation of a large tumor and organ-metastasis within 3 weeks in SCID mice. This review briefly focuses on the role of SDF-1/CXCR4 interaction in tumor growth and metastasis of breast cancer cell both in vitro and in vivo. (c) 2006 Elsevier SAS. All rights reserved.
引用
收藏
页码:273 / 276
页数:4
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