Unlocking the potential of the human genome with RNA interference

被引：852

作者：

Hannon, GJ

Rossi, JJ

机构：

[1] Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

[2] Grad Sch Biol Sci, Beckman Res Inst City Hope, Div Mol Biol, Duarte, CA 91010 USA

来源：

NATURE | 2004年 / 431卷 / 7006期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature02870

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The discovery of RNA interference (RNAi) may well be one of the transforming events in biology in the past decade. RNAi can result in gene silencing or even in the expulsion of sequences from the genome. Harnessed as an experimental tool, RNAi has revolutionized approaches to decoding gene function. It also has the potential to be exploited therapeutically, and clinical trials to test this possibility are already being planned.

引用

页码：371 / 378

页数：8

共 101 条

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