A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer

被引:55
作者
Ribeiro, Ricardo
Araujo, Ana Paula
Coelho, Ana
Catarino, Raquel
Pinto, Daniela
Araujo, Antonio
Calcada, Carmen
Lopes, Carlos
Medeiros, Rui
机构
[1] Inst Portugues Oncol Francisco Gentil, Mol Oncol CI, P-4200072 Oporto, Portugal
[2] Inst Portugues Oncol Francisco Gentil, Dept Med Oncol, P-4200072 Oporto, Portugal
[3] Inst Portugues Oncol Francisco Gentil, Dept Radiotherapy, P-4200072 Oporto, Portugal
[4] Univ Porto, Abel Salazar Inst Biomed Sci, ICBAS, P-4100 Oporto, Portugal
关键词
leptin; lung cancer; genetic polymorphism; risk; cigarette smoke;
D O I
10.1016/j.ejca.2006.02.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Leptin hormone and receptor have been associated to cancer development and were identified in lung tissue. In this study, a functional polymorphism in the S' flanking region of the leptin gene (LEP-2548G/A) was found to increase susceptibility for non-small cell lung cancer [odds ratio (OR), 1.97; 95% confidence interval (Cl), 1.13-3.43]. Age-adjusted logistic regression analysis in men indicated an association of AA genotype with adenocarcinoma (OR, 4.29; CI, 1.64-11.72) and squamous cell carcinoma (OR, 3.19; Cl, 1.26-8.13). Logistic regression analysis confirmed the AA genotype as an independent risk factor for lung cancer after adjustment for age and gender (OR, 2.57; CI, 1.34-4.92). The AA genotype was overrepresented only in patients with non-metastatic disease (OR, 1.86; Cl, 1.13-3.04). Kaplan-Meier analysis demonstrated an earlier age of onset for lung cancer in AA carriers (P = 0.023). Results suggest the existence of genetic susceptibility for lung cancer in carriers of this LEP functional polymorphism. Further studies are warranted to extend knowledge of leptin involvement in lung cancer. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1188 / 1193
页数:6
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