Nanomaterials and bone regeneration

被引：495

作者：

Gong, Tao ^{[1
]}

Xie, Jing ^{[1
]}

Liao, Jinfeng ^{[1
]}

Zhang, Tao ^{[1
]}

Lin, Shiyu ^{[1
]}

Lin, Yunfeng ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

来源：

BONE RESEARCH | 2015年 / 3卷

基金：

中国国家自然科学基金;

关键词：

TISSUE ENGINEERING SCAFFOLDS; STEM-CELL FATE; ELECTROSPUN NANOFIBERS; EXTRACELLULAR-MATRIX; GROWTH-FACTORS; IN-VITRO; MORPHOLOGY; DELIVERY; MICROSTRUCTURE; NANOCOMPOSITES;

D O I：

10.1038/boneres.2015.29

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

The worldwide incidence of bone disorders and conditions has been increasing. Bone is a nanomaterials composed of organic (mainly collagen) and inorganic (mainly nano-hydroxyapatite) components, with a hierarchical structure ranging from nanoscale to macroscale. In consideration of the serious limitation in traditional therapies, nanomaterials provide some new strategy in bone regeneration. Nanostructured scaffolds provide a closer structural support approximation to native bone architecture for the cells and regulate cell proliferation, differentiation, and migration, which results in the formation of functional tissues. In this article, we focused on reviewing the classification and design of nanostructured materials and nanocarrier materials for bone regeneration, their cell interaction properties, and their application in bone tissue engineering and regeneration. Furthermore, some new challenges about the future research on the application of nanomaterials for bone regeneration are described in the conclusion and perspectives part.

引用

页数：7

共 38 条

[1]

Spatial control of adult stem cell fate using nanotopographic cues [J].