Do young hepatocellular carcinoma patients have worse prognosis? The paradox of age as a prognostic factor in the survival of hepatocellular carcinoma patients

被引:62
作者
Chen, Chien-Hung
Chang, Ting-Tsung
Cheng, Ken-Sheng
Su, Wei-Wen
Yang, Sheng-Shun
Lin, Hans Hsienhong
Wu, Shun-Sheng
Lee, Chuan-Mo
Changchien, Chi-Sin
Chen, Chien-Jen
Sheu, Jin-Chuan
Chen, Ding-Shinn
Lu, Sheng-Nan [1 ]
机构
[1] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan
[2] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan
[3] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan
[4] China Med Univ Hosp, Dept Internal Med, Div Gastroenterol, Taichung, Taiwan
[5] Changhua Christian Hosp, Dept Internal Med, Changhua, Taiwan
[6] Taichung Vet Gen Hosp, Dept Internal Med, Taichung, Taiwan
[7] Tzu Chi Gen Hosp, Dept Gastroenterol, Hualien, Taiwan
[8] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Hepatogastroenterol, Kaohsiung, Taiwan
[9] Chang Gung Univ, Taoyuan, Taiwan
[10] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10764, Taiwan
[11] Natl Taiwan Univ, Coll Med, Hepatitis Res Ctr, Taipei 10764, Taiwan
关键词
HBsAg; hepatocellular carcinoma; survival; Taiwan; young;
D O I
10.1111/j.1478-3231.2006.01309.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Our previous study showed that male hepatocellular carcinoma (HCC) patients below 40 years of age had the worst survival in the initial several years, but had the best prognosis thereafter. Thus, it seems that age has a paradoxical influence on the prognosis. To further clarify the issue of age on HCC prognosis, we initiated this study. Methods: A total of 11 312 HCC cases from seven medical centers from 1986 to 2002 were included. We analyzed the 1-year survival and survival after 1 year. Results: Male gender, age younger than 40 years old and hepatitis B virus (HBV) were associated with worse 1-year survival. In contrast, male gender, age younger than 40 years old and HBV were associated with better survival after 1 year. Higher percentage of the young HCC patients had a tumor size larger than 3 cm. 83.7% of HCC patients below 40 years of age were male and 89.8% of them were HBV carriers. Conclusions: If we encountered a young HCC patient, the patient will probably be a male HBV carrier. He would probably have larger tumor and is more likely to expire within 1 year than the older HCC patients. However, if the young HCC patient can survive for more than 1 year, he would probably have better survival in the following years than the older patients.
引用
收藏
页码:766 / 773
页数:8
相关论文
共 35 条
  • [31] Hepatitis B e antigen and the risk of hepatocellular carcinoma
    Yang, HI
    Lu, SN
    Liaw, YF
    You, SL
    Sun, CA
    Wang, UY
    Hsiao, CK
    Chen, PJ
    Chen, DS
    Chen, CJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (03) : 168 - 174
  • [32] Hepatic resection and prognosis for patients with hepatocellular carcinoma larger than 10 cm: Two decades of experience at Chang Gung Memorial Hospital
    Yeh, CN
    Lee, WC
    Chen, MF
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2003, 10 (09) : 1070 - 1076
  • [33] Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: A prospective study in men
    Yu, MW
    Yeh, SH
    Chen, PJ
    Liaw, YF
    Lin, CL
    Liu, CJ
    Shih, WL
    Kao, JH
    Chen, DS
    Chen, CJ
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (04): : 265 - 272
  • [34] Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives
    Yu, MW
    Chang, HC
    Liaw, YF
    Lin, SM
    Lee, SD
    Liu, CJ
    Chen, PJ
    Hsiao, TJ
    Lee, PH
    Chen, CJ
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (14) : 1159 - 1164
  • [35] Surgery for large primary liver cancer more than 10 cm in diameter
    Zhou, XD
    Tang, ZY
    Ma, ZC
    Wu, ZQ
    Fan, J
    Qin, LX
    Zhang, BH
    [J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2003, 129 (09) : 543 - 548