Ganoderic acid Me induces G1 arrest in wild-type p53 human tumor cells while G1/S transition arrest in p53-null cells

被引：38

作者：

Chen, Nian-Hong ^{[2
]}

Zhong, Jian-Jiang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Key Lab Microbial Metab, Sch Life Sci & Biotechnol, Minist Educ, Shanghai 200240, Peoples R China

[2] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Sch Biotechnol, Shanghai 200237, Peoples R China

来源：

PROCESS BIOCHEMISTRY | 2009年 / 44卷 / 08期

关键词：

Ganoderic acid; p53; Cell cycle; Ganoderic acid Me (GA-Me); Anti-tumor activity; Traditional Chinese medicine (TCM); BREAST-CANCER CELLS; ANTITUMOR-ACTIVITY; INHIBIT GROWTH; CYCLE ARREST; LUCIDUM; APOPTOSIS; CHEMOPREVENTION; EXPRESSION; TRITERPENE; EXTRACTS;

D O I：

10.1016/j.procbio.2009.03.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism of cell cycle arrest of tumor cells induced by ganoderic acid Me (GA-Me) is not understood. In this work, GA-Me was found to possess remarkable cytotoxicity on highly metastatic lung carcinoma 95-D cell line in both dose- and time-dependent manners. The effect of GA-Me on cell cycle arrest was found in 95-D, p53-null lung cancer cells H 1299, HCT-116 p53(+/+) and HCT-116 p53(-/-) human colon cancer cells. To obtain an insight into the role of p53 in cell cycle arrest by GA-Me, 95-D, H1299, HCT-116 p53(+/+) and HCT-116 p53(-/-) cells were used for further investigation. GA-Me arrested cell cycle at G, phase in 95-D and HCT-116 p53(+/+) cells while 5 phase or G(1)/S transition arrest in H1299 and HCT-116 p53(-/-) cells. The results suggested that p53 may be a target of CA-Me, and it may be looked at as a new promising candidate for the treatment of carcinoma cells. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：928 / 933

页数：6

共 26 条

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