Microwave assisted synthesis and crystals structures of 2-imidazolines and imidazoles

被引：37

作者：

de la Hoz, Antonio ^{[1
]}

Diaz-Ortiz, Angel

Mateo, Maria del Carmen

Moral, Monica

Moreno, Andres

Elguero, Jose

Foces-Foces, Concepcion

Rodriguez, Matias L.

Sanchez-Migallon, Ana

机构：

[1] Univ Castilla La Mancha, Fac Ciencias Quim, Dept Quim Inorgan Organ & Bioquim, E-13071 Ciudad Real, Spain

[2] CSIC, Inst Quim Med, E-28006 Madrid, Spain

[3] CSIC, Inst Quim Fis Rocasolano, Dept Cristalog, E-28006 Madrid, Spain

[4] Univ La Laguna, CSIC, Inst Bioorgan, E-38206 Tenerife, Spain

来源：

TETRAHEDRON | 2006年 / 62卷 / 25期

关键词：

D O I：

10.1016/j.tet.2006.04.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-imidazolines and imidazoles has been synthesized using green synthetic methodologies. The preparation of 2-imidazolines was performed by cyclization of nitriles with ethylenediamine. The use of microwave irradiation in solvent-free conditions enabled 2-imidazolines to be obtained in high yields within short reaction times. Aromatization of imidazoles was performed under microwave irradiation in toluene and using Magtrieve (TM) as the oxidant. The X-ray structures for five of these derivatives are provided. In all cases, the molecules are assembled into chains through N-(HN)-N-... hydrogen bonds. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5868 / 5874

页数：7

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