Self-tolerance of natural killer cells

被引：431

作者：

Raulet, David H. ^{[1
]}

Vance, Russell E. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Canc Res Lab, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 07期

关键词：

D O I：

10.1038/nri1863

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells, similar to other lymphocytes, acquire tolerance to self. This means that NK cells have the potential to attack normal self cells but that there are mechanisms to ensure that this does not usually occur. Self-tolerance is acquired by NK cells during their development, but the underlying molecular and cellular mechanisms remain poorly understood. Recent studies have produced important new information about NK-cell self-tolerance. Here, we review the evidence for and against possible mechanisms of NK-cell self-tolerance, with an emphasis on the role of MHC-specific receptors.

引用

页码：520 / 531

页数：12

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