Isoquinoline Synthesis via Rhodium-Catalyzed Oxidative Cross-Coupling/Cyclization of Aryl Aldimines and Alkynes

被引：410

作者：

Guimond, Nicolas ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 34期

基金：

加拿大自然科学与工程研究理事会;

关键词：

C-H ACTIVATION; POMERANZ-FRITSCH REACTION; INTERNAL ALKYNES; ELECTROPHILIC CYCLIZATION; TERMINAL ACETYLENES; PYRIDINES; IMINES; IMINOANNULATION; DERIVATIVES; CLEAVAGE;

D O I：

10.1021/ja904380q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general. rhodium-catalyzed oxidative coupling reaction between internal alkynes and aryl aldimines is described. This process affords 3,4-disubstituted isoquinolines in good yield and high regioselectivity. Preliminary mechanistic studies suggest that the C-N bond formation arises from the reductive elimination of a rhodium(III) species.

引用

页码：12050 / +

页数：4

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