Pathogenic significance of IgA receptor interactions in IgA nephropathy

被引：70

作者：

Monteiro, RC

Moura, IC

Launay, P

Tsuge, T

Haddad, E

Benhamou, M

Cooper, MD

Arcos-Fajardo, M

机构：

[1] Bichat Med Sch, INSERM, E0225, F-75870 Paris 18, France

[2] Hop Robert Debre, Div Pediat Nephrol, F-75019 Paris, France

[3] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Pathol, Boston, MA 02215 USA

[4] Univ Alabama Birmingham, Howard Hughes Med Inst, Birmingham, AL 35294 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2002年 / 8卷 / 10期

关键词：

D O I：

10.1016/S1471-4914(02)02405-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, frequently progresses to renal failure. The pathogenesis of this disease involves the deposition of undergalactosylated IgA1 complexes in the glomerular mesangium. How the IgA1 complexes are generated and why they are deposited in the mesangium remains unclear. We propose a model wherein two types of IgA receptors participate in sequential steps to promote the development of IgAN, with FcalphaRI (CD89) being initially involved in the formation of circulating IgA-containing complexes and, subsequently, transferrin receptor (CD71) in mediating mesangial deposition of IgA1 complexes.

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收藏

页码：464 / 468

页数：5

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