Asymmetric synthesis of 4,4-disubstituted-2-cyclohexen-1-ones from a chiral 2-(trimethylsilyl)benzamide

被引：7

作者：

Schultz, AG

Pettus, L

机构：

[1] Department of Chemistry, Rensselaer Polytechnic Institute, Troy

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 31期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)01215-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Birch reduction-alkylation of the chiral 2-(trimethylsilyl)benzamide 4 provides 1,4-cyclohexadienes 5b-5e with diastereomer ratios of >100:1. The conversions of 5b-5e to the 4,4-disubstituted-2-cyclohexen-1-ones 8b-8e are described. (C) 1997 Elsevier Science Ltd.

引用

页码：5433 / 5436

页数：4

共 15 条

[11] Asymmetric total synthesis of (+)-apovincamine and a formal synthesis of (+)-vincamine. Demonstration of a practical ''asymmetric linkage'' between aromatic carboxylic acids and chiral acyclic substrates [J].