STRL22 is a receptor for the CC chemokine MIP-3 alpha

被引：87

作者：

Liao, F

Alderson, R

Su, J

Ullrich, SJ

Kreider, BL

Farber, JM

机构：

[1] NIAID,CLIN INVEST LAB,NIH,BETHESDA,MD 20892

[2] HUMAN GENOME SCI INC,ROCKVILLE,MD 20850

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 236卷 / 01期

关键词：

D O I：

10.1006/bbrc.1997.6936

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

STRL22 is a human seven transmembrane domain orphan receptor related to known chemokine receptors and expressed in peripheral blood lymphocytes, tumor infiltrating lymphocytes and lymphoid tissues. MIP-3 alpha/LARC/Exodus is a CC chemokine that is chemotactic for lymphocytes and that is expressed in activated cells, including monocytes, T cells, endothelial cells, and fibroblasts, and in liver, lung, and some lymphoid tissues. We report here that STRL22-transfected human embryonic kidney 293 cells demonstrated specific binding for MIP-3 alpha and that MIP-3 alpha, but no other chemokines, produced a calcium flux in freshly-isolated peripheral blood lymphocytes and we show that MIP-3 alpha also produced a signal in tumor infiltrating lymphocytes that express STRL22. Since STRL22 is the sixth functional CC chemokine receptor identified, it should be re-named CCR6. (C) 1997 Academic Press.

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页码：212 / 217

页数：6

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