Germinal-centre reactions in allergic inflammation

被引：43

作者：

Gould, Hannah J. ^{[1
]}

Takhar, Pooja

Harries, Helen E.

Durham, Stephen R.

Corrigan, Christopher J.

机构：

[1] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England

[2] Imperial Coll Sch Med, Natl Heart & Lung Inst, Allergy & Clin Immunol Sect, London SW3 6LY, England

[3] Kings Coll London, Div Allergy Asthma & Lung Biol, London SE1 9RT, England

[4] Kings Coll London, MRC & Asthma UK Ctr Allerg Mechanisms Asthma, London SE1 1UL, England

来源：

TRENDS IN IMMUNOLOGY | 2006年 / 27卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.it.2006.08.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary and secondary immune responses in the germinal centres of lymphoid organs have been studied in the past. There is now compelling evidence of a third stage in the immune response, in 'tertiary lymphoid organs' that develop at sites of chronic inflammation in response to persistent local antigen challenge. Germinal-centre-like reactions are well-documented in the target organs of autoimmune diseases. Here, we review recent evidence that they also occur at sites of allergic inflammation.

引用

页码：446 / 452

页数：7

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