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Survival of a bacterioferritin deletion mutant of Brucella melitensis 16M in human monocyte-derived macrophages

被引：14
作者：
Denoel, PA
Crawford, RM
Zygmunt, MS
Tibor, A
Weynants, VE
Godfroid, F
Hoover, DL
Letesson, JJ
机构：
[1] INRA, PATHOL INFECT & IMMUNOL LAB, F-37380 NOUZILLY, FRANCE
[2] ARMED FORCES INST PATHOL, DEPT INFECT & PARASIT DIS, WASHINGTON, DC 20306 USA
[3] WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA
来源：
INFECTION AND IMMUNITY | 1997年 / 65卷 / 10期
关键词：
D O I：
10.1128/IAI.65.10.4337-4340.1997
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A bacterioferritin (BFR) deletion mutant of Brucella melitensis 16M was generated by gene replacement. The deletion was complemented with a broad-host-range vector carrying the wild-type bfr gene, pBBR-bfr. The survival and growth of the mutant, B. melitensis PAD 2-78, were similar to those of its parental strain in human monocyte-derived macrophages (MDM). These results suggest that BFR is not essential for the intracellular survival of B. melitensis in human MDM.
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收藏
页码：4337 / 4340
页数：4
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