Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

被引：33

作者：

Kamal, A ^{[1
]}

Ramulu, P ^{[1
]}

Srinivas, O ^{[1
]}

Ramesh, G ^{[1
]}

Kumar, PP ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 18期

关键词：

pyrrolobenzodiazepine; benzimidazoles; hoechst-33258; DNA-binding ability; cytotoxicity;

D O I：

10.1016/j.bmcl.2004.06.069

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity. (C) 2004 Published by Elsevier Ltd.

引用

页码：4791 / 4794

页数：4

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