A new metal-organic polymeric system capable of stimuli-responsive controlled release of the drug ibuprofen

被引：22

作者：

Belen Lago, Ana ^{[1
]}

Pino-Cuevas, Arantxa ^{[1
]}

Carballo, Rosa ^{[1
]}

Vazquez-Lopez, Ezequiel M. ^{[1
]}

机构：

[1] Univ Vigo, Dept Quim Inorgan, Fac Quim, IBI, Vigo 36310, Galicia, Spain

来源：

DALTON TRANSACTIONS | 2016年 / 45卷 / 04期

关键词：

TWISTED LIGANDS 4,4'-DIPYRIDYLDISULFIDE; COORDINATION POLYMERS; COMPLEXES; BIS(4-PYRIDYLTHIO)METHANE; CONFORMATION; FRAMEWORKS; CRYSTAL; ZN(II); ACIDS; ZINC;

D O I：

10.1039/c5dt04031k

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

A series of new zinc compounds has been prepared easily under mild synthetic conditions with the drug ibuprofen incorporated as a ligand to form different coordination polymers. The host materials have a high drug content and exhibit high stability, low cytotoxicity, good biodegradability and high biocompatibility. The ion exchange mechanism involved in the ibuprofen release process and the pH-controlled drug release have been studied.

引用

页码：1614 / 1621

页数：8

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