Synthesis and SAR of 4-(1H-benzimidazole-2-carbonyl)piperidin with dual histamine H1/tachykinin NK1 receptor antagonist activity

被引：11

作者：

Maynard, GD

Bratton, LD

Kane, JM

Burkholder, TP

Santiago, R

Stewart, KT

Kudlacz, EM

Shatzer, SA

Knippenberg, RW

Farrell, AM

Logan, DE

机构：

[1] Hoechst Marion Roussel, Inc., Cincinnati, OH 45215-6300

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(97)10097-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H-1/tachykinin NK1 receptor antagonist activity has been prepared, Factors affecting receptor binding affinities and oral activity in this series are described. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：2819 / 2824

页数：6

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