A CONVERGENT SYNTHESIS OF 4-(2-BENZOTHIAZOYL)PIPERIDINES WITH ANTIHISTAMINIC ACTIVITY

被引：8

作者：

MAYNARD, GD

CHENG, HC

KANE, JM

STAEGER, MA

机构：

[1] Marion Merrell Dow Research Institute, Cincinnati, OH 45215-6300

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81268-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 4-(N-methoxy-N-methylcarboxamido)-1-piperidinecarboxylic acid 1,]-dimethylethyl ester (5) is described. Reaction of this intermediate with 2-lithiobenzothiazole followed by deprotection and N-alkylation yields a series of 4-(2-benzothiazoyl)piperidines with potent antihistaminic activity.

引用

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页码：753 / 756

页数：4

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