Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism

被引：250

作者：

Vasiliou, V ^{[1
]}

Pappa, A ^{[1
]}

Estey, T ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Sch Pharm,Dept Pharmaceut Sci, Mol Toxicol & Environm Hlth Sci Program, Denver, CO 80262 USA

来源：

DRUG METABOLISM REVIEWS | 2004年 / 36卷 / 02期

关键词：

aldehyde dehydrogenases; human; metabolism; lipid peroxidation; polymorphisms;

D O I：

10.1081/DMR-120034001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The human genome contains at least 17 genes that are members of the aldehyde dehydrogenase (ALDH) superfamily. These genes encode NAD(P)(+)-dependent enzymes that oxidize a wide range of aldehydes to their corresponding carboxylic acids. Aldehydes are highly reactive molecules that are intermediates or products involved in a broad spectrum of physiologic, biologic, and pharmacologic processes. Aldehydes are generated during retinoic acid biosynthesis and the metabolism of amino acids, lipids, carbohydrates, and drugs. Mutations in several ALDH genes are the molecular basis of inborn errors of metabolism and contribute to environmentally induced diseases.

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收藏

页码：279 / 299

页数：21

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共 119 条

[11] NUTRITIONAL FOLATE-DEFICIENCY IN CHINESE-HAMSTER OVARY CELLS .1. CHARACTERIZATION OF THE PLEIOTROPIC RESPONSE AND ITS MODULATION BY NUCLEIC-ACID PRECURSORS [J].

BORMAN, LS ;

BRANDA, RF .

JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 140 (02) :335-343

[12]

BUNTING KD, 1994, J BIOL CHEM, V269, P23197

[13] Protection by transfected rat or human class 3 aldehyde dehydrogenases against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines - Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme [J].

Bunting, KD ;

Townsend, AJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (20) :11891-11896

[14] Evidence of oxidative damage in Alzheimer's disease brain:: central role for amyloid β-peptide [J].

Butterfield, DA ;

Drake, J ;

Pocernich, C ;

Castegna, A .

TRENDS IN MOLECULAR MEDICINE, 2001, 7 (12) :548-554

[15] SUCCINIC SEMIALDEHYDE DEHYDROGENASE FROM MAMMALIAN BRAIN - SUBUNIT ANALYSIS USING POLYCLONAL ANTISERUM [J].

CHAMBLISS, KL ;

GIBSON, KM .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1992, 24 (09) :1493-1499

[16] Molecular characterization of methylmalonate semialdehyde dehydrogenase deficiency [J].

Chambliss, KL ;

Gray, RGF ;

Rylance, G ;

Pollitt, RJ ;

Gibson, KM .

JOURNAL OF INHERITED METABOLIC DISEASE, 2000, 23 (05) :497-504

[17] IDENTIFICATION OF A HERITABLE DEFICIENCY OF THE FOLATE-DEPENDENT ENZYME 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE IN MICE [J].

CHAMPION, KM ;

COOK, RJ ;

TOLLAKSEN, SL ;

GIOMETTI, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) :11338-11342

[18] Purification, N-terminal sequence determination and enzymatic characterization of antiquitin from the liver of grass carp [J].

Chan, WM ;

Tang, WK ;

Cheng, CHK ;

Fong, WP .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2003, 136 (03) :443-450

[19] POLYMORPHISM OF ALCOHOL AND ALDEHYDE DEHYDROGENASE GENES AND ALCOHOLIC CIRRHOSIS IN CHINESE PATIENTS [J].

CHAO, YC ;

LIOU, SR ;

CHUNG, YY ;

TANG, HS ;

HSU, CT ;

LI, TK ;

YIN, SJ .

HEPATOLOGY, 1994, 19 (02) :360-366

[20] HUMAN ALDEHYDE DEHYDROGENASE E3 ISOZYME IS A BETAINE ALDEHYDE DEHYDROGENASE [J].

CHERN, MK ;

PIETRUSZKO, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 213 (02) :561-568

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