Intracellular mRNA localization: motors move messages

被引：117

作者：

Tekotte, H ^{[1
]}

Davis, I ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, ICMB, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 12期

关键词：

D O I：

10.1016/S0168-9525(02)02819-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Intracellular mRNA localization is a common mechanism of post-transcriptional regulation of gene expression. In a wide range of organisms, mRNA localization coupled with translational regulation target the proteins to their site of function. Here,we describe recent exciting evidence that some mRNAs are transported as particles along the cytoskeleton by the molecular motors dynein, kinesin or myosin. We discuss the key questions of how localized mRNAs might be linked to motors and what determines their cytoptasmic destinations.

引用

页码：636 / 642

页数：7

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