One-pot synthesis of (±)-crispine A and its C-ring-substituted analogs

被引：48

作者：

Meyer, Nino ^{[1
]}

Opatz, Till ^{[1
]}

机构：

[1] Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 17期

关键词：

natural products; heterocycles; umpolung; 1,4-addition; amino nitriles;

D O I：

10.1002/ejoc.200600314

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward access to crispine A and C-ring-substituted analogs by 1,4-addition of a deprotonated a-amino nitrile to alpha,beta-unsaturated carbonyl compounds is described. If the reduction step is omitted, substituted 5,6-dihydropyrrolo[2,1a]isoquinolines can be obtained. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

引用

页码：3997 / 4002

页数：6

共 15 条

[1] SYNTHESIS OF 1-(AMINOMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINES AND THEIR ACTIONS AT ADRENOCEPTORS INVIVO AND INVITRO [J].