Quality of life and seizure control in patients with brain tumor-related epilepsy treated with levetiracetam monotherapy: preliminary data of an open-label study

被引：29

作者：

Dinapoli, Loredana ^{[1
]}

Maschio, Marta ^{[1
]}

Jandolo, Bruno ^{[1
]}

Fabi, Alessandra ^{[2
]}

Pace, Andrea

Sperati, Francesca ^{[3
]}

Muti, Paola ^{[4
]}

机构：

[1] Natl Inst Canc Regina Elena, Dept Neurosci & Cerv Facial Pathol, Ctr Tumor Related Epilepsy, I-00137 Rome, Italy

[2] Natl Inst Canc Regina Elena, Dept Oncol, I-00144 Rome, Italy

[3] Natl Inst Canc Regina Elena, SC Epidemiol, I-00144 Rome, Italy

[4] Natl Inst Canc Regina Elena, Sci Direct, I-00144 Rome, Italy

来源：

NEUROLOGICAL SCIENCES | 2009年 / 30卷 / 04期

关键词：

Levetiracetam; Brain tumor-related epilepsy; Efficacy; Quality of life; LOW-GRADE GLIOMAS; ANTIEPILEPTIC DRUGS; COGNITIVE FUNCTION; CHEMOTHERAPY; RADIOTHERAPY; SURVIVAL;

D O I：

10.1007/s10072-009-0087-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this pilot study was to investigate the effects of levetiracetam monotherapy on seizure control, quality of life and neurocognitive performance in patients with brain tumor-related epilepsy. We present here preliminary data from 18 patients with follow-up of 6 months. We evaluated seizure frequency at baseline. We used administered Mini Mental State Examination (MMSE), Karnofsky Performance Status (KPS), Barthel index (BI), QOLIE 31P (V2), EORTC QLQ-C30 and Adverse Events Profile. After 6 months, 16 patients were seizure free (88.9%), 2 (11.1%) had reduction in seizure frequency > 50%. Compared to baseline, we observed a worsening of performance (KPS p = 0.011; BI = 0.008) and global lower cognitive performance (MMSE p = 0.011); distress related to seizure frequency (p = 0.003) and medication effects (p = 0.046) were significantly lower. Levetiracetam caused mild and reversible side effects. These preliminary data on LEV monotherapy in patients with brain tumor-related epilepsy show that this antiepileptic drug is efficacious and well tolerated.

引用

页码：353 / 359

页数：7

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