Angiogenic factors in endometriosis

被引：248

作者：

Taylor, RN ^{[1
]}

Lebovic, DI ^{[1
]}

Mueller, MD ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Ctr Reprod Sci, San Francisco, CA 94143 USA

来源：

ENDOMETRIOSIS: EMERGING RESEARCH AND INTERVENTION STRATEGIES | 2002年 / 955卷

关键词：

neovascularization; vascular endothelial growth factor (VEGF); estrogen receptors; cytokines;

D O I：

10.1111/j.1749-6632.2002.tb02769.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Similar to tumor metastases, endometriotic implants require neovascularization to establish, grow, and invade. The peritoneal environment is ideally suited to provide a proangiogenic milieu. Nevertheless, endometriotic lesions are found only in a minority of reproductive-age women (similar to10%) with retrograde menstruation. In this paper, we review the major cytokines, growth factors, steroid hormones, and eicosanoids responsible for angiogenesis in endometriosis. We postulate that interference with angiogenic principles expressed in the peritoneum may constitute novel therapeutic opportunities for the prevention, amelioration, or treatment of pelvic endometriosis.

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页码：89 / 100

页数：12

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