A selective reductive amination of aldehydes by the use of Hantzsch dihydropyridines as reductant

被引：103

作者：

Itoh, T ^{[1
]}

Nagata, K ^{[1
]}

Miyazaki, M ^{[1
]}

Ishikawa, H ^{[1
]}

Kurihara, A ^{[1
]}

Ohsawa, A ^{[1
]}

机构：

[1] Showa Univ, Sch Pharmaceut Sci, Shinagawa Ku, Tokyo, Japan

来源：

TETRAHEDRON | 2004年 / 60卷 / 31期

关键词：

aldehyde; ketone; direct reductive amination; imine; Hantzsch dihydropyridine; scandium (III) triflate; Lewis acid;

D O I：

10.1016/j.tet.2004.05.096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct reductive amination of an aldehyde was carried out using a Hantzsch dihydropyridine as the reductant in the presence of a catalytic amount of scandium triflate. The reaction was highly selective towards aldehydes over ketones, and other reducible functional groups did not affect the reaction. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6649 / 6655

页数：7

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