Cancer stem cell hypothesis in thyroid cancer

被引：60

作者：

Zhang, Ping ^{[1
]}

Zuo, Hui ^{[1
]}

Ozaki, Takashi ^{[1
]}

Nakagomi, Nami ^{[1
]}

Kakudo, Kennichi ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Pathol, Wakayama 6415809, Japan

来源：

PATHOLOGY INTERNATIONAL | 2006年 / 56卷 / 09期

关键词：

cancer stem cell; embryogenesis; mixed medullary and follicular carcinoma; stem cell; thyroid;

D O I：

10.1111/j.1440-1827.2006.01995.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

There is increasing evidence that many types of cancer contain their own stem cells: cancer stem cells, which are characterized by their self-renewing capacity and differentiation ability. Cancer could be regarded as an abnormal organ initiated by cancer stem cells, and cancer stem cells might play a decisive role in tumor initiation and progression. Dysregulation of stem cell self-renewal is a likely requirement for the development of cancer, and stem cells seem more likely to be the transformed target cells in carcinogenesis. This cancer stem cell model has great implications for understanding of oncogenesis and treatment for cancer. Abundant evidence suggests that, parallel to other solid tumors, cancer stem cells also exist in thyroid cancer, although their characteristics are largely unknown to date. The present review will discuss the potential traits of cancer stem cells in thyroid cancer and their transformation targets: stem cells in the thyroid gland.

引用

页码：485 / 489

页数：5

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