Extracellular Vesicles as Novel Delivery Tools for Cancer Treatment

被引：9

作者：

Erkan, Erdogan Pekcan ^{[1
,2
]}

Saydam, Okay ^{[3
]}

机构：

[1] Dokuz Eylul Univ, Izmir Biomed & Genome Ctr, Izmir, Turkey

[2] Dokuz Eylul Univ, Dept Neurosci, Inst Hlth Sci, Izmir, Turkey

[3] Med Univ Vienna, Dept Pediat & Adolescent Med, Vienna, Austria

来源：

CURRENT CANCER DRUG TARGETS | 2016年 / 16卷 / 01期

基金：

欧盟第七框架计划;

关键词：

Cancer; delivery; extracellular vesicles; therapeutics; CELL-DERIVED EXOSOMES; MEDIATED TRANSFER; MULTIVESICULAR BODY; DENDRITIC CELLS; MESSENGER-RNAS; MICROVESICLES; PROTEINS; BIOGENESIS; MICRORNA; SECRETION;

D O I：

10.2174/1568009615666150923115439

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Extracellular vesicles (EVs) are different types of membrane-derived vesicles that originate from the endosomal pathway or the plasma membrane. These vesicles are used as "carriers" in intercellular communication, and are responsible for the transfer of biological cargo (lipids, proteins, RNA species, and DNA) between different cells. Despite the shortcomings in our knowledge of EV biology, attempts to employ EVs as natural delivery tools for therapeutic purposes have been partly successful in different settings. In this review, we highlight this unique potential of EVs, and discuss previous examples and future scenarios.

引用

页码：34 / 42

页数：9

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