Zoledronic acid decreases gene expression of vascular endothelial growth factor and basic fibroblast growth factor by human epithelial cells

被引：13

作者：

Basso, Fernanda G. ^{[1
]}

Turrioni, Ana Paula S. ^{[2
]}

Hebling, Josimeri ^{[2
]}

de Souza Costa, Carlos Alberto ^{[2
]}

机构：

[1] Univ Estadual Campinas, Piracicaba Sch Dent, BR-13414903 Piracicaba, SP, Brazil

[2] Univ Estadual Paulista, UNESP, Araraquara Sch Dent, BR-14801903 Araraquara, SP, Brazil

来源：

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY | 2013年 / 51卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

Epithelial cells; VEGF; bFGF; Tissue healing; Bisphosphonates;

D O I：

10.1016/j.bjoms.2013.05.010

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Delayed wound healing in patients taking bisphosphonates could result from decreased expression of growth factors, which are directly related to cell proliferation and migration. In this study, we evaluated the gene expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bEGF) by epithelial cells exposed to zoledronic acid 5 mu mol for 48 h using real-time polymerase chain reaction. The gene expression of VEGF and bFGF by epithelial cells exposed to zoledronic acid decreased by 34% and 51%, respectively (p=0.0001 and p=0.0001). We conclude that zoledronic acid can decrease the expression of growth factors by epithelial cells. (C) 2013 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

引用

页码：971 / 973

页数：3

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