The mitochondrial processing peptidase

被引：28

作者：

Braun, HP ^{[1
]}

Schmitz, UK ^{[1
]}

机构：

[1] UNIV HANNOVER,INST ANGEW GENET,D-30419 HANNOVER,GERMANY

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1997年 / 29卷 / 8-9期

关键词：

protein processing; protein import; bc(1) complex; mitochondria;

D O I：

10.1016/S1357-2725(97)00032-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The mitochondrial processing peptidase (MPP) is a heterodimeric enzyme which plays an essential role in mitochondrial protein import, It cleaves off the N-terminal targeting signals of nuclear encoded mitochondrial proteins upon their transport into the organelle, In mammals and yeast the enzyme is localized in the mitochondrial matrix while in plants it is integrated into a protein complex of the respiratory chain, As the activity of MPP is essential for the viability of eukaryotic cells it is conceivable that inhibitors of MPP which are specific for the soluble enzyme only present in fungi and animals may work as fungicides or insecticides, (C) 1997 Elsevier Science Ltd.

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页码：1043 / 1045

页数：3

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