Direct observation of intramolecular hydrogen bonds in peptide 310 helices by 3hJN,C′ scalar couplings

被引：6

作者：

Bellanda, M

Rainaldi, M

Broxterman, QB

Kaptein, B

Formaggio, F

Crisma, M

Mammi, S

Toniolo, C

机构：

[1] Univ Padua, Dept Chem, I-35131 Padua, Italy

[2] CNR ICB, Padova Unit, I-35131 Padua, Italy

[3] Adv Synth & Catalysis, DSM Pharma Chem, NL-6160 MD Geleen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 24期

关键词：

helical structures; IR spectroscopy; NMR spectroscopy; peptides; X-ray diffraction;

D O I：

10.1002/anie.200454224

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Differentiating helices: The direct observation of hydrogen bonds by 3hJN,C′ scalar couplings (see picture) is not only possible for α-helix and β-sheet peptides and proteins, but for 310-helical peptides as well. The method also provides information on terminal fraying of helices and allows the discrimination between α and 310 helices.

引用

页码：3152 / 3155

页数：4

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