Me or not me? The danger of spontaneity

被引：27

作者：

Greinacher, Andreas ^{[1
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Greifswald, Germany

来源：

BLOOD | 2014年 / 123卷 / 23期

关键词：

HEPARIN-INDUCED THROMBOCYTOPENIA; PLATELET-FACTOR-4;

D O I：

10.1182/blood-2014-04-566836

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Warkentin et al provide insight into certain rare but often catastrophic cases of thrombotic complications, termed spontaneous" (or "autoimmune") heparin-induced thrombocytopenia (HIT). © 2014 by The American Society of Hematology."

引用

页码：3536 / 3538

页数：5

共 10 条

[1] Anti-platelet factor 4/heparin antibodies in patients with impaired graft function after liver transplantation [J].

Bakchoul, T. ;

Assfalg, V. ;

Zoellner, H. ;

Evert, M. ;

Novotny, A. ;

Matevossian, E. ;

Friess, H. ;

Hartmann, D. ;

Hron, G. ;

Althaus, K. ;

Greinacher, A. ;

Hueser, N. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2014, 12 (06) :871-878

[2] T-independent immune response: New aspects of B cell biology [J].

Fagarasan, S ;

Honjo, T .

SCIENCE, 2000, 290 (5489) :89-92

[3] Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4 [J].

Jaax, Miriam E. ;

Krauel, Krystin ;

Marschall, Thomas ;

Brandt, Sven ;

Gansler, Julia ;

Fuerll, Birgitt ;

Appel, Bettina ;

Fischer, Silvia ;

Block, Stephan ;

Helm, Christiane A. ;

Mueller, Sabine ;

Preissner, Klaus T. ;

Greinacher, Andreas .

BLOOD, 2013, 122 (02) :272-281

[4] Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes [J].

Krauel, Krystin ;

Weber, Claudia ;

Brandt, Sven ;

Zaehringer, Ulrich ;

Mamat, Uwe ;

Greinacher, Andreas ;

Hammerschmidt, Sven .

BLOOD, 2012, 120 (16) :3345-3352

[5] Platelet factor 4 binds to bacteria-inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia [J].

Krauel, Krystin ;

Poetschke, Christian ;

Weber, Claudia ;

Kessler, Wolfram ;

Fuerll, Birgitt ;

Ittermann, Till ;

Maier, Stefan ;

Hammerschmidt, Sven ;

Broeker, Barbara M. ;

Greinacher, Andreas .

BLOOD, 2011, 117 (04) :1370-1378

[6] Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia [J].

Sachais, Bruce S. ;

Rux, Ann H. ;

Cines, Douglas B. ;

Yarovoi, Serge V. ;

Garner, Lee I. ;

Watson, Stephen P. ;

Hinds, Jillian L. ;

Rux, John J. .

BLOOD, 2012, 119 (25) :5955-5962

[7] Delayed-onset heparin-induced thrombocytopenia and thrombosis [J].

Warkentin, TE ;

Kelton, JG .

ANNALS OF INTERNAL MEDICINE, 2001, 135 (07) :502-506

[8] Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder [J].

Warkentin, Theodore E. ;

Basciano, Paul A. ;

Knopman, Jared ;

Bernstein, Richard A. .

BLOOD, 2014, 123 (23) :3651-3654

[9] B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia [J].

Zheng, Yongwei ;

Wang, Alexander W. ;

Yu, Mei ;

Padmanabhan, Anand ;

Tourdot, Benjamin E. ;

Newman, Debra K. ;

White, Gilbert C. ;

Aster, Richard H. ;

Wen, Renren ;

Wang, Demin .

BLOOD, 2014, 123 (06) :931-934

[10] Critical role for mouse marginal zone B cells in PF4/heparin antibody production [J].

Zheng, Yongwei ;

Yu, Mei ;

Podd, Andrew ;

Yuan, Liudi ;

Newman, Debra K. ;

Wen, Renren ;

Arepally, Gowthami ;

Wang, Demin .

BLOOD, 2013, 121 (17) :3484-3492

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