Timolol maleate release from pH-sensible poly(2-hydroxyethyl methacrylate-co-methacrylic acid) hydrogels

被引：56

作者：

García, DM

Escobar, JL

Noa, Y

Bada, N

Hernáez, E

Katime, I

机构：

[1] Univ Basque Country, Fac Ciencias, Dept Quim Fis, Grp Nuevos Mat & Espectroscopia Supramol, E-48080 Bilbao, Spain

[2] Univ La Habana, Ctr Biomat, Havana, Cuba

来源：

EUROPEAN POLYMER JOURNAL | 2004年 / 40卷 / 08期

关键词：

hydrogel; timolol; pH-sensible;

D O I：

10.1016/j.eurpolymj.2004.03.012

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Multifunctional polymeric materials were obtained from poly(methacrylic acid-co-2-hydroxyethyl methacrylate), to be used as a raw material in the manufacture of contact lens and as drug delivery systems. Poly(methacrylic acid-co-2-hydroxyethyl methacrylate) was prepared by free-radical polymerization in aqueous solution at 60degreesC using potassium persulfate (KPS) as initiator and N,N'-methylenebisacrylamide (BIS) as cross-linker agent. The dynamic and equilibrium swelling properties of dry glassy poly(methacrylic acid-co-2-hydroxyethyl methacrylate) polymeric networks were studied as a function of pH and methacrylic acid (MAA) content. The water content increase as MAA content and pH increase. Timolol maleate delivery from poly(MAA) and poly(2-hydroxyethyl methacrylate) (HEMA) homopolymers was studied and the results show a Fickian diffusion behavior. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1683 / 1690

页数：8

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