Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response

被引：154

作者：

Comhair, SAA

Bhathena, PR

Dweik, RA

Kavuru, M

Erzurum, SC

机构：

[1] Cleveland Clin Fdn, Dept Pulm & Crit Care Med, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Lerner Res Inst, Cleveland, OH 44195 USA

来源：

LANCET | 2000年 / 355卷 / 9204期

关键词：

D O I：

10.1016/S0140-6736(99)04736-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Loss of superoxide dismutase activity occurs within minutes of an acute asthmatic response to segmental antigen instillation into the lung of individuals with atopic asthma. Decreased activity undoubtedly contributes to airway inflammation and injury through increased formation of reactive oxygen and nitrogen species, and suggests that enrichment of lung antioxidants is therapeutic for asthma.

引用

页码：624 / 624

页数：1

共 5 条

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