Molecular mechanisms of testosterone action in spermatogenesis

被引：140

作者：

Walker, William H. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Magee Womens Res Inst, Dept Cell Biol & Physiol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Magee Womens Res Inst, Ctr Res Reprod Physiol, Pittsburgh, PA 15213 USA

来源：

STEROIDS | 2009年 / 74卷 / 07期

关键词：

Testis; Non-genomic; MAP kinase; Transcription; Signal transduction; Src kinase; GROWTH-FACTOR RECEPTOR; ACTIVATED PROTEIN-KINASE; ADHERENS JUNCTION DYNAMICS; CELL-SELECTIVE KNOCKOUT; ANDROGEN RECEPTOR; SERTOLI-CELLS; RAT TESTIS; SEMINIFEROUS EPITHELIUM; ESTROGEN-RECEPTOR; PLASMA-MEMBRANE;

D O I：

10.1016/j.steroids.2008.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Testosterone is required for the maturation of male germ cells, the production of sperm and thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic processes have not been well defined. In this review, classical and non-classical pathways of testosterone signaling in the Sertoli cells of the testis are discussed in relation to testosterone-regulated processes that are required for spermatogenesis. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：602 / 607

页数：6

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