Absolute configuration of 2-hydroxy-2-(1-naphthyl)propionic acid as determined by the 1H NMR anisotropy method

被引：36

作者：

Ichikawa, A

Hiradate, S

Sugio, A

Kuwahara, S

Watanabe, M

Harada, N

机构：

[1] Natl Inst Sericultural & Entomol Sci, Dept Insect Technol, Tsukuba, Ibaraki 3058634, Japan

[2] Natl Inst Agroenvironm Sci, Dept Environm Biol, Tsukuba, Ibaraki 3058604, Japan

[3] Tohoku Univ, Inst Chem React Sci, Aoba Ku, Sendai, Miyagi 9808577, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 21期

关键词：

D O I：

10.1016/S0957-4166(99)00451-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantiopure 2-hydroxy-2-(1-naphthyl)propionic acid (+)-2 was prepared by the stereoselective Grignard reaction of 1-naphthylmagnesium bromide with (1R,3R,4S)-menthyl pyruvate 3 or (1R,3R,4S)-8-phenylmenthyl pyruvate 4, and the absolute configuration of acid (+)-2 was unambiguously determined to be S by the H-1 NMR anisotropy method. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4075 / 4078

页数：4

共 12 条

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