Versatile Pd(OTf)2.2H2O-Catalyzed ortho-Fluorination Using NMP as a Promoter

被引：318

作者：

Wang, Xisheng ^{[1
]}

Mei, Tian-Sheng ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 22期

基金：

美国国家科学基金会;

关键词：

REDUCTIVE ELIMINATION; ENANTIOSELECTIVE FLUORINATION; REACTIVITY;

D O I：

10.1021/ja901352k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd(OTf)(2)center dot 2H(2)O-catalyzed ortho-fluorination of triflamide-protected benzylamines is reported. The use of N-fluoro-2,4,6-trimethylpyridinium triflate as the F+ source and NMP as a promoter is crucial for this reaction. The conversion of triflamide into a wide range of synthetically useful functional groups makes this fluorination protocol broadly applicable in medicinal chemistry and synthesis.

引用

页码：7520 / +

页数：3

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