CraA, a Major Facilitator Superfamily Efflux Pump Associated with Chloramphenicol Resistance in Acinetobacter baumannii

被引：86

作者：

Roca, I. ^{[2
,3
]}

Marti, S.

Espinal, P.

Martinez, P. ^{[2
,3
]}

Gibert, I. ^{[2
,3
]}

Vila, J. ^{[1
]}

机构：

[1] Univ Barcelona, Fac Med,IDIBAPS, Microbiol Serv,Sch Med, Ctr Diagnost Biomed,Hosp Clin,Dept Microbiol, Barcelona 7, Spain

[2] Univ Autonoma Barcelona, Inst Biotecnol & Biomed, E-08193 Barcelona, Spain

[3] Univ Autonoma Barcelona, Dept Genet & Microbiol, Grp Genet Mol Bacteriana, E-08193 Barcelona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 09期

关键词：

MULTIDRUG-RESISTANCE; CALCOACETICUS; MUTAGENESIS; TRANSPOSON; PLASMIDS; SEQUENCE; PROTEIN; SYSTEM; ADEIJK; GENES;

D O I：

10.1128/AAC.00584-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Acinetobacter baumannii has been increasingly associated with hospital-acquired infections, and the presence of multidrug resistance strains is of great concern to clinicians. A. baumannii is thought to possess a great deal of intrinsic resistance to several antimicrobial agents, including chloramphenicol, although the mechanisms involved in such resistance are not well understood. In this work, we have identified a major facilitator superfamily efflux pump present in most A. baumannii strains, displaying strong substrate specificity toward chloramphenicol.

引用

页码：4013 / 4014

页数：2