DSCAM and DSCAML1 Function in Self-Avoidance in Multiple Cell Types in the Developing Mouse Retina

被引：188

作者：

Fuerst, Peter G. ^{[1
]}

Bruce, Freyja ^{[2
]}

Tian, Miao ^{[3
]}

Wei, Wei ^{[5
]}

Elstrott, Justin ^{[5
]}

Feller, Maria B. ^{[5
]}

Erskine, Lynda ^{[2
]}

Singer, Joshua H. ^{[3
,4
]}

Burgess, Robert W. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] Univ Aberdeen, Sch Med Sci, Aberdeen AB25 2ZD, Scotland

[3] Northwestern Univ, Feinberg Sch Med, Dept Ophthalmol, Chicago, IL 60611 USA

[4] Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USA

[5] Univ Calif Berkeley, Dept Mol Cell Biol, Berkeley, CA 94720 USA

来源：

NEURON | 2009年 / 64卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 美国国家卫生研究院;

关键词：

AXON GUIDANCE; DROSOPHILA DSCAM; ADHESION MOLECULE; NETRIN RECEPTOR; DIVERSITY; RECOGNITION; EXPRESSION; NEURONS; SYNAPSE; GENES;

D O I：

10.1016/j.neuron.2009.09.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental functions, including axon guidance, synaptic adhesion, and self-avoidance, depending on the species, cell type, and gene family member studied. We examined the function of DSCAM and DSCAML1 in the developing mouse retina. In addition to a subset of amacrine cells, Dscaml1 was expressed in most retinal ganglion cells (RGCs). RGCs had fasciculated dendrites and clumped cell bodies in Dscam(-/-) mice, suggesting a role in self-avoidance. Dscaml1 was expressed in the rod circuit, and mice lacking Dscaml1 had fasciculated rod bipolar cell dendrites and clumped All amacrine cell bodies, also indicating a role in self-avoidance. Neurons in Dscam or Dscaml1 mutant retinas stratified their processes appropriately in synaptic laminae in the inner plexiform layer, and functional synapses formed in the rod circuit in mice lacking Dscaml1. Therefore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic specificity in the mouse retina.

引用

页码：484 / 497

页数：14

共 47 条

[1] Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion [J].