Usefulness of Mendelian Randomization in Observational Epidemiology

被引：62

作者：

Bochud, Murielle ^{[1
]}

Rousson, Valentin ^{[1
]}

机构：

[1] Univ Inst Social & Prevent Med, CH-1005 Lausanne, Switzerland

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2010年 / 7卷 / 03期

关键词：

genetic epidemiology; causality; observational studies; instrumental variables; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; HORMONE-BINDING GLOBULIN; STRUCTURAL MEAN MODELS; SERUM CONCENTRATIONS; CARDIOVASCULAR RISK; METABOLIC SYNDROME; CAUSAL INFERENCE; CONTROLLED TRIAL; YOUNG FINNS;

D O I：

10.3390/ijerph7030711

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. In this review, we recall the principles of a. Mendelian randomization. approach in observational epidemiology, which is based on the technique of instrumental variables; we provide simulations and an example based on real data to demonstrate its implications; we present the results of a systematic search on original articles having used this approach; and we discuss some limitations of this approach in view of what has been found so far.

引用

页码：711 / 728

页数：18

共 67 条

[1]

ALMON R, 2009, EUR J NUTR IN PRESS

[2] Stillbirth and slow metabolizers of caffeine: comparison by genotypes [J].

Bech, Bodil Hammer ;

Autrup, Herman ;

Nohr, Ellen Aagaard ;

Henriksen, Tine Brink ;

Olsen, Jorn .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2006, 35 (04) :948-953

[3] Aldehyde Dehydrogenase 2 and Head and Neck Cancer: A Meta-analysis Implementing a Mendelian Randomization Approach [J].

Boccia, Stefania ;

Hashibe, Mia ;

Galli, Paola ;

De Feo, Emma ;

Asakage, Takahiro ;

Hashimoto, Tomoko ;

Hiraki, Akio ;

Katoh, Takahiko ;

Nomura, Takeshi ;

Yokoyama, Akira ;

van Duijn, Cornelia M. ;

Ricciardi, Gualtiero ;

Boffetta, Paolo .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (01) :248-254

[4] A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology [J].

Bochud, Murielle ;

Chiolero, Arnaud ;

Elston, Robert C. ;

Paccaud, Fred .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2008, 37 (02) :414-416

[5] Association between C-Reactive Protein and Adiposity in Women [J].

Bochud, Murielle ;

Marquant, Fabienne ;

Marques-Vidal, Pedro-Manuel ;

Vollenweider, Peter ;

Beckmann, Jacques S. ;

Mooser, Vincent ;

Paccaud, Fred ;

Rousson, Valentin .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (10) :3969-3977

[6] Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype [J].

Brennan, Paul ;

McKay, James ;

Moore, Lee ;

Zaridze, David ;

Mukeria, Anush ;

Szeszenia-Dabrowska, Neonilia ;

Lissowska, Jolanta ;

Rudnai, Peter ;

Fabianova, Eleonora ;

Mates, Dana ;

Bencko, Vladimir ;

Foretova, Lenka ;

Janout, Vladimir ;

Chow, Wong-Ho ;

Rothman, Nathaniel ;

Chabrier, Amelie ;

Gaborieau, Valerie ;

Timpson, Nic ;

Hung, Rayjean J. ;

Smith, George Davey .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2009, 38 (04) :971-975

[7] Inflammation, insulin resistance, and diabetes-mendelian randomization using CRP haplotypes points upstream [J].

Brunner, Eric J. ;

Kivimaeki, Mika ;

Witte, Daniel R. ;

Lawlor, Debbie A. ;

Smith, George Davey ;

Cooper, Jackie A. ;

Miller, Michelle ;

Lowe, Gordon D. O. ;

Rumley, Ann ;

Casas, Juan P. ;

Shah, Tina ;

Humphries, Steve E. ;

Hingorani, Aroon D. ;

Marmot, Michael G. ;

Timpson, Nicholas J. ;

Kumari, Meena .

PLOS MEDICINE, 2008, 5 (08) :1278-1286

[8]

Casas JP, 2005, LANCET, V365, P224, DOI 10.1016/S0140-6736(05)70152-5

[9] Insight into the nature of the CRP-coronary event association using Mendelian randomization [J].

Casas, Juan P. ;

Shah, Tina ;

Cooper, Jackie ;

Hawe, Emma ;

McMahon, Alex D. ;

Gaffney, Dairena ;

Packard, Christopher J. ;

O'Reilly, Denis S. ;

Juhan-Vague, Irene ;

Yudkin, John S. ;

Tremoli, Elena ;

Margaglione, Maurizio ;

Di Minno, Giovanni ;

Hamsten, Anders ;

Kooistra, Teake ;

Stephens, Jeffrey W. ;

Hurel, Steven J. ;

Livingstone, Shona ;

Colhoun, Helen M. ;

Miller, George J. ;

Bautista, Leonelo E. ;

Meade, Tom ;

Sattar, Naveed ;

Humphries, Steve E. ;

Hingorani, Aroon D. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2006, 35 (04) :922-931

[10] Sequence variations in PCSK9, low LDL, and protection against coronary heart disease [J].

Cohen, JC ;

Boerwinkle, E ;

Mosley, TH ;

Hobbs, HH .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (12) :1264-1272

← 1 2 3 4 5 6 7 →