Functional Abnormalities in the Dyslexic Brain: A Quantitative Meta-Analysis of Neuroimaging Studies

被引：370

作者：

Richlan, Fabio ^{[1
,2
]}

Kronbichler, Martin ^{[1
,2
,3
]}

Wimmer, Heinz ^{[1
,2
]}

机构：

[1] Salzburg Univ, Dept Psychol, A-5020 Salzburg, Austria

[2] Salzburg Univ, Ctr Neurocognit Res, A-5020 Salzburg, Austria

[3] Paracelsus Private Med Univ, Christian Doppler Clin, Dept Neurol, Salzburg, Austria

来源：

HUMAN BRAIN MAPPING | 2009年 / 30卷 / 10期

基金：

奥地利科学基金会;

关键词：

dyslexia; reading; magnetic resonance imaging; positron-emission tomography; cerebral cortex; DEVELOPMENTAL DYSLEXIA; CORTICAL ORGANIZATION; NEURAL BASIS; CHILDREN; LANGUAGE; WORDS; ACTIVATION; SYSTEMS; FMRI; NEUROANATOMY;

D O I：

10.1002/hbm.20752

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study used foci from 17 original studies on functional abnormalities in the dyslexic brain to identify brain regions with consistent under- or overactivation. Studies were included when reading or reading-related tasks were performed on visually presented stimuli and when results reported coordinates for group differences. Activation likelihood estimation (ALE) was used for quantification. Maxima of underactivation were found in inferior parietal, superior temporal, middle and inferior temporal, and fusiform regions of the left hemisphere. With respect to left frontal abnormalities, we found underactivation in the inferior frontal gyrus to be accompanied by overactivation in the primary motor cortex and the anterior insula. Tentative functional interpretations of the activation abnormalities are provided. Hum Brain Mapp 30:3299-3308, 2009. (C) 2009 Wiley-Liss, Inc.

引用

页码：3299 / 3308

页数：10

共 61 条

[1] Functional MRI of language: New approaches to understanding the cortical organization of semantic processing [J].